Uncoupling cellular and molecular mechanisms of intestinal regeneration protein targets and action mechanisms of novel anticancer agents.

29 Nov 2002 The uncoupling proteins (UCPs) are transporters, present in the mitochondrial inner membrane, that mediate a regulated discharge of the

Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Antimicrobial agents and chemotherapy - 2014-01-01. surfaces - Test methods - Part 1: Ceramic tile surfaces with incorporated antibacterial agents ISO 23215, Uncoupling Membrane for Ceramic Tile Installation. Influence of the nature of pre-contraction on the responses to commonly employed vasodilator agents in rat-isolated aortic rings The following vasoconstrictor Uncoupling proteins as a therapeutic target to protect the diabetic heart2018Ingår i: Pharmacological Research, ISSN 1043-6618, E-ISSN 1096-1186, Vol. 137 data with the in vitro system does not support the idea of a direct interaction between a mitochondrial protein and the uncoupling agents as proposed earlier. av P Spiteller · 2015 · Citerat av 95 — and Egyptian history.8 Yet ergot fungi as the causative agents were not uncoupling the oxidative phosphorylation in the host plant.263. av C Piot · 2008 · Citerat av 1439 — lapse of the membrane potential, the uncoupling Thrombolytic agents (failed).

including SMEs (e.g. by uncoupling tax reporting and financial reporting in since the pre-tax interest rates reflect what reporting agents pay on deposits and An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain. The result is that the cell or mitochondrion expends energy to generate a proton motive force, but the proton motive force is dissipated before the ATP synthase can recapture this energy and use it to make ATP. Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes. [from MeSH] Salicylic acid is also an uncoupling agent (chiefly in plants) and will decrease production of ATP and increase body temperature if taken in extreme excess.

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those Mitochondrial Uncoupling Agents Trigger Ventricular Fibrillation in Isolated Rat Hearts. Hatcher, A Shea BS ; Alderson, Julie M BS ; Clements-Jewery, Hugh PhD .

"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Uncoupling compounds short-circuit the proton gradient that is normally built up in the intermembrane space during electron transport, by reversing the proton flux from the intermembrane space back into the matrix ( Fig. 21-10 ). Serien fick en fristående uppföljare trettio år senare i serien Get Smart men även tidigare med filmen Agent 86 med rätt att göra bort sig från 1980, TV-filmen Agent 86 Smart från 1989 samt senare med filmen Get Smart från 2008..

Salicylic acid is also an uncoupling agent (chiefly in plants) and will decrease production of ATP and increase body temperature if taken in extreme excess. Uncoupling proteins are increased by thyroid hormone , norepinephrine , epinephrine , and leptin .

In cellular respiration, oxidation of "fuel" in the mitochondrion is coupled to the phosphorylation of ADP, forming ATP. Uncouplers are chemicals that allow oxidation to proceed without producing the usual amount of ATP. In the Electron The invention provides the use of a water-soluble biocide as an uncoupling agent at an effective amount to control bacterial biomass in an aqueous system. The invention also provides a method for controlling the growth of bacterial biomass in an aqueous system. "Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. "Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).

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Uncoupling proteins are increased by thyroid hormone , norepinephrine , epinephrine , and leptin . Uncoupling Agents Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes. How to pronounce uncoupling agents? Description Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur.

Human translations with examples: uncoupling agents.
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data with the in vitro system does not support the idea of a direct interaction between a mitochondrial protein and the uncoupling agents as proposed earlier.

(see also oxidative phosphorylation) Uncoupling Agents - definition. Definition: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur.. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial m Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

Salicylic acid is also an uncoupling agent (chiefly in plants) and will decrease production of ATP and increase body temperature if taken in extreme excess. Uncoupling proteins are increased by thyroid hormone , norepinephrine , epinephrine , and leptin .

In a preferred embodiment the method comprises contacting an effective amount of an uncoupling agent which is a water-soluble biocide directly with the bacterial biomass in an aqueous system. Uncoupling of oxidative phosphorylation (OXPHOS) by nonsteroidal antiinflammatory drugs can occur via protonophoretic activity and other mechanisms. At physiological pH, many carboxylic acids (or sulfonamides) are present as anions; they are protonated in the mitochondrial intermembrane space and can permeate into the matrix, where they are deprotonated again due to the inside negative membrane potential. Uncoupling agents; 2,4-Dinitrophenol (DNP) Carbonyl cyanide p-[trifluoromethoxy]-phenyl-hydrazone (FCCP) Oligomycin (inhibitor of oxidative phosphorylation) With the exception of malonate and cyanide, these poisons are much more soluble in ethanol than in water. Study of these latter substances, the uncoupling agents, reveals further subgrouping: 1) those agents which stimulate oxygen consumption and are insensitive to magnesium ion changes (e.g., dinitrophenol) and 2) agents which do not stimulate oxygen consumption while depressing phosphorylation and whose action is reversed by magnesium ions (e.g., the tetracyclines). The significance of this difference remains to be explained.

Why does this work? Why would this be dangerous?